(book showcasing in-ADME)
(updated Jan. 2019)
• Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs
• pKa-critical Interpretations of Solubility–pH Profiles: PG 300995 and NSC-639829 Case Studies
• Determining pKa values at 37`C from available values at 25`C.
• Novel method correcting in situ brain perfusion flow-limited permeability of lipophilic molecules.
• P-gp KO mouse in situ brain perfusion permeability and its prediction using in combo PAMPA.
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Adriatic port city of Split, dating to Roman times, venue for IAPC-8.
• IAPC-8 Meeting: Physico Chemical Methods Drug Discovery Development – Split, Croatia (9-11 Sep 2019). Co-organizing and co-chairing with Prof. Christel Bergström (Uppsala) a special session: State-of-the-Art Solubility Methods in Drug Development. Speakers to be announced soon.
• IAPC-7 & PCF-J Meeting: Physico Chemical Methods Drug Discovery Development – Ritsumeikan Univ., Osaka, Japan (27-30 Aug 2018). Presented 3 lectures: (1) Biophysical Model of Drug Absorption based on Rat/Human Perfusion Data Linked to Caco-2 Permeability; (2) Capillary Flow Hydrodynamics and Carrier-Mediated Transport of Opioid Derivatives at the BBB: Crone-Renkin-pH and Michaelis-Menten-pH Analyses; (3) Ksp of Drug Salts and Cocrystals: Simulations to Improve Design of Experiments According to the Interlaboratory Consensus Recommendations.
• IAPC-6 Meeting: Physico Chemical Methods Drug Discovery Development – Zagreb, Croatia (4-7 Sep 2017): Five lectures presented: (1) Biophysical Model for Drug Absorption: (a) using Caco-2/MDCK & PAMPA; (2) ... (b) in Rat Jejunum & Colon; (3) ... (c) Human Jejunum; (4) Both Passive & Carrier-Mediated Uptake are Important in Drug Disposition; (5) Cocrystal Dissolution-pH Mechanistic Models: Aqueous Boundary Layer Convection-Diffusion-Reaction in Rotating Disk/Powder Methods. Chaired Special Session: Pharmaceutical Cocrystals – Physicochemical Properties and Formulations: speakers - N. Rodríguez-Hornedo (Univ. Michigan), R. Prohens (Univ. Barcelona), R. Hilfiker (Solvias AG), A. Serajuddin (St. John's Univ.), N. Fotaki (Bath Univ.), A. Avdeef (in-ADME Research).
• College of Pharmacy, University of Michigan – Ann Arbor (21 Sep 2016). Presented: Solubility/Dissolution-pH Data Analysis with Auto-Generation of Equilibrium Equations- Applications in Solubility Product (Ksp) and Dissolution Measurements of Cocrystals.
• Hong Kong Polytechnic University – HK (29 Aug 2016). Presented: Both Passive & Carrier-Mediated Uptake are Important in Drug Disposition.
• IAPC-5 Meeting: Physico-Chemical Methods in Drug Discovery and Development – Zhuhai, China (23-26 Aug 2016). Presented 3 lectures: (1) Both Passive and Carrier-Mediated Uptake are Important in Drug Dispositon; (2) Data Mining for Equilibrium Solubility of Ionizable Druglike Molecules; (3) Cocrystal Solubility-pH Data Analysis using pDISOL-X (with Automatic Equilibrium Equation Generation).
• Fosun Pharmaceuticals – Shanghai, China (19 Aug 2016). Presented: Salt Solubility, Solubility Product (Ksp), and Sub-Micellar Aggregation Measurement of Surface-Active Drugs in Phosphate Buffer Media.
• SIMM (Shanghai Institute of Material Medica) – Shanghai, China (18 Aug 2016). Presented: in vivo and in vitro Models - Rate of Brain Penetration by Drugs.
• Harbin Medical University Pharmaceutical Department – Harbin, China (2 Aug 2016). Presented: in vivo and in vitro Models - Rate of Brain Penetration by Drugs.
• St. John's University – New York (20 July 2016). Presented: Solubility/Dissolution-pH Data Analysis with Auto-Generation of Equilibrium Equations – Applications in Solubility Product and Dissolution Measurements of Salts and Cocrystals.
• Pion Inc. 20th Anniversary Meeting: Annual Advanced Fiber Optic Workshop – Billerica, MA (23 May 2016). Presented: The Importance of Knowing the pKa Accurately in Physicochemical Profiling.
• Univ. of Barcelona, Spain (12-16 Nov 2015). Presented 2-day, 8-lecture "Mini-Course": Physicochemical Profiling in Drug Discovery and Early Development.
• Univ. of Seville, Spain (6-10 Nov 2015). Presented 2-day, 8-lecture "Mini-Course": Physicochemical Profiling in Drug Discovery and Early Development. Also presented departmental lecture: Measurement of Salt Solubility, Solubility Product (Ksp), and Sub-Micellar Aggregation of Surface Active Drugs in Phosphate Buffer Media.
• IAPC-4 Meeting: Physico-Chemical Methods in Drug Discovery and Development – Red Island/Rovinj, Croatia (18-24 Sep 2015). Presented 3 lectures: (1) Both Passive and Carrier-Mediated Uptake are Important in Drug Dispositon; (2) Salt Solubility & Solubility Product (Ksp) Measurement – New Perspectives in Support of Salt Selection; (3) Data Mining for Equilibrium (Non-Amorphous) Solubility of Druglike Molecules. Chaired Special Session: Improving Methods for Determining Solubility: speakers - K. Takács-Novák (Semmel Weiss Univ., E. Fuguet (Univ. Barcelona), A. Llinàs (AstraZeneca), A. Avdeef (in-ADME Research).
• Participated in the Doctoral School Intensive Course on Permeability, pKa and Solubility Measurements at the University of Tartu, Estonia (20-26 Sep 2014), conducting 5 lectures and consultations with graduate students and faculty. The event will be hosted by Prof. Uko Maran from the Instute of Chemistry.
• in-ADME Research will attend Barriers of the CNS Gordon Conf., Colby Sawyer Coll., NH (15-20 Jun 2014), presenting a poster on: "in combo Prediction of Kp,uu"
• Rev 4.02 of pCEL-X is here (free 30-day download), featuring prediction of unbound-drug bain-to-plasma ratio, Kp,uu, total-drug brain-to-plasma ratio, Kp, and unbound-drug fraction in plasma, fu,plasma (23 Apr 2014).
• in-ADME Research has attended Solubility & Bioavailability Enhancement Workshop, Ascendia Pharmaceuticals, N. Brunswick, NJ (28 Apr 2014), presenting a talk on: "Salt solubility determination, complicated by the presence of drug aggregates, drug-buffer precipitates, and co-precipitates."
• in-ADME Research attends 5th FIP Pharm. Sci. World Congress, Melbourne, Australia (13-16 Apr 2014), presenting a talk: "Both passive lipoidal diffusion and carrier-mediated uptake are important transport mechanisms in drug disposition."
• in-ADME Research has attended the annual AAPS meeting 10-14 Nov 2013 in San Antonio: presented 3 posters & debated Prof. Douglas Kell: "Gradient on my nerves: a debate on the importance passive diffusion vs. carrier-mediated transport in drug disposition?"
• Rev 3.0 of pDISOL-X is here (free 30-day download). SALT SOLUBILITY analysis successfully tested using 247 published log S - pH profiles. Also, state-of-the-art analysis for DISSOLUTION processes involving poorly-soluble ionizable drugs, using CONVECTIVE-DIFFUSION & SIMUL-TANEOUS CHEMICAL REACTION model, with Vinograd-McBain electric field treatment - the finishing touches to pioneering works of Higuchi, Mooney-Stella, McNamara-Amidon, & Southard. (6 Nov 2013).
• Wiki-pKaTM in TOOLS has expanded to 1107 pKa values & 286 ref. Many CE-based values added.
• in-ADME Research has attended 3rd World Conf. on Physico Chemical Methods in Drug Discovery & Development in Dubrovnik, 22-26 Sept 2013, and presented FIVE talks.
• Rev 4.0 of pCEL-X is here (free 30-day download), featuring unbound-drug BRAIN EXPOSURE prediction & SNAPSHOT PREVIEW (blood-brain barrier PS, Caco-2 Papp, human Peff (in vivo) and human Loc-I-Gut Peff values (30 Sep 2012).
• in-ADME Research attends Barriers of the CNS Gordon Conf., Colby Sawyer Coll., NH (17-22 Jun 2012), lecturing on: "Barrier Permeability & in vitro Models for Predicting It."
• in-ADME Research attends 10th EDAN in Leuven, Belgium (25-27 Mar 2012), lecturing: "Cell & Artificial Memebrane Models Predicting Human Jejunal Permeability – a Question of Scaling?"