Photo Gallery in-ADME Research

(updated Jan. 2019; Copyright in-ADME Research 2011-2019.)

 

IAPC-6 Meeting: Physico Chemical Methods Drug Discovery Development – Zagreb, Croatia (4-7 Sep 2017).
The young man with the hat is Prof. Kiyohiko Sugano (Ritsumeikan U.), and in the front center is Prof.
Tatjana Verbic (U. of Belgrade).

Alex Avdeef visiting Prof. Nair Rodríguez-Hornedo and her students at the College of Pharmacy,
Univ. of Michigan – Ann Arbor & demonstrating pDISOL-X for cocrystal solubility-pH analysis (21 Sep 2016).

Alex Avdeef presenting lecture at Hong Kong Polytechnic University – HK (29 Aug 2016).

Profs. Godefridus J. Peters (VU Univ. Medical Center, The Netherlands), Zoran Mandic (Univ. Zagreb,
Croatia), and Kiyohiko Sugano (Sitsumeikan Univ., Osaka, Japan). APC-5 Meeting: Physico-Chemical
Methods in Drug Discovery and Development – Zhuhai, China (23-26 Aug 2016).

APC-5 Meeting: Physico-Chemical Methods in Drug Discovery and Development – Zhuhai, China
(23-26 Aug 2016). Top front: Dr. Rolf Hilfiker, Solvias AG, Switerland. Right: Prof. Kwok-Yin Wong
(Hong Kong Polytechnic U., HK, China).

Alex Avdeef seminar at Suntech Fosun Pharmaceuticals – Shanghai, China (19 Aug 2016): Salt
Solubility, Solubility Product (Ksp), and Sub-Micellar Aggregation Measurement of Surface-Active
Drugs in Phosphate Buffer Media.

Presentation at SIMM (Shanghai Institute of Material Medica) – Shanghai, China (18 Aug 2016).
Above, left: Mr. Gavin Li (Shanghai), distributor for in-ADME Research pCEL-X and pDISOL-X software products.

Alex Avdeef speaks on drug penetration into the brain at the Harbin Medical Univ. Pharmaceutical
Dept.in Harbin, China (2 Aug 2016). The presenter was born in Harbin. Clockwise: St. Sophia
church. His maternal grandfather, Lavr Michaelevich Gvozdëv financed and built the church from
1923 to 1932. Now it is a noted museum in the center of Pristan district of the city, not far from Sungari
River. Next are the former Czech, German, and American consulates of Harbin. Next. the prominent
Hotel Moderne, center of the Kaspe family tragedy in 1933. Two scenes from Kitaiskaya St, where
some grand buildings still remain. Finally, an old "dacha" (summer country home) on the other side
of Sungari River.

in-ADME Research Mini-Course (2-day, 8-lecture: "Physicochemical Profiling in Drug Discovery
and Early Development") presentation at Univ. of Barcelona, Spain (12-16 Nov 2015). At the front are
Profs. Xavier Subirats, Elisabeth Bosch, Martí Rosés, and Elisabet Fuguet. It may have been Prof.
Clara Ràfols who took the photo.

Alex Avdeef presents departmental seminar at Univ. of Seville, Spain (6-10 Nov 2015). Also, the
Mini-Course (2-day, 8-lecture: "Physicochemical Profiling in Drug Discovery and Early Development")
was presented. Prof. Agustin García Asuero (top left), along with his colleagues, including Prof. & Dean
Jose Manuel Vega, Prof. Benito Valdés (Pres. of Inst. Royal Acad. Andalusia), Prof. Alberto Machado,
were the most kind and gracious hosts.

Venue for the IAPC-3 Conference in Dubrovnik, Croatia (22-26 Sep 2013). Walled city on the Adriatic
coast from the 15th Century; listed as a UNESCO World Heritage site.

IAPC-3 Conference on Physico-Chemical Methods in Drug Discovery and Development, Dubrovnik,
Croatia (22-26 Sep 2013).

IAPC-3 Conference on Physico-Chemical Methods in Drug Discovery and Development, Dubrovnik,
Croatia (22-26 Sep 2013). The person at the very top is Prof. Tatjana Verbic (Univ. of Belgrade). Dr. Alan
Hill (GSK) is on the far right.

IAPC-3 Conference on Physico-Chemical Methods in Drug Discovery and Development, Dubrovnik,
Croatia (22-26 Sep 2013). Touring the ancient city and relaxing amongst friends and colleagues.
The seated person at the center is Dr. Manfred Kansy (Hoffman-La Roche, Basel).

IAPC-3 Conference on Physico-Chemical Methods in Drug Discovery and Development, Dubrovnik,
Croatia (22-26 Sep 2013). A chance to tour the ancient city and relax amongst friends and colleagues.
The three persons in the lower right view are Dr. Robert Fraczkiewicz (Simulations Plus, USA),
Dr. Alan Hill (GSK, UK), and Prof. Kin Tam (Univ. Macau, China).

IAPC-3 Conference on Physico-Chemical Methods in Drug Discovery and Development, Dubrovnik,
Croatia (22-26 Sep 2013). A chance to tour the ancient city and relax amongst friends and colleagues.

Kell-Avdeef: "Gradient On My Nerves: A debate on the Importance Passive Diffusion vs. Carrier-Mediated
Transport in Drug Disposition?" at 2013 AAPS National Meeting in San Antonio. Kell and coworkers (2008
-2015) put forward a controversial 'theory' that carrier-mediated transport accounts for all the cellular
uptake of pharmaceuticals, and that passive lipoidal diffusion of drugs across phospholipid bilayer
portion of cell membranes plays no role. However, this suggestion has met with some pushback and has
had limited acceptance within the membrane permeability and transport scientific community. Ten
publications emerged surrounding the spirited controversy, the last three being: (8) Smith D, et al.,
2014. Mol. Pharmaceutics, 11, 1727−1738.; (9) Kell DB, 2015. Trends Pharmacol. Sci., 36, 15-21;
(10) Zheng Y, et al., 2015. Pharm. Res. 10.1007/s11095-015-1640-3.

Kell-Avdeef debate at 2013 AAPS National Meeting in San Antonio. Top left, slightly back: Prof.
Malcolm Rowland (Univ. Manchester), smiling is Dr. Sibylle Neuhoff (Simcyp – Certara, UK). Top
right is Prof. Dhiren Thakker (U. North Carolina) asking a question. Bottom left is Prof. Margareta
Hammarlund-Udenaes (Uppsala U.), and bottom right is Prof. David Smith (U. Michigan) posing some
vibrant questions, as Dr. David Turner (Simcyp-Certara, hands folded) takes it in. After the debate,
many participants were drawn to a local pub for libations of reconciliation.

in-ADME Research Mini-Course quiz award winners. Left: Univ. of Tartu, 2014, with Mare Oja on the
left. Right: Hanan Fael wins the quiz award at Univ. of Barcelona, 2015. Note the GLpKa/D-PAS
instruments in the background.

in-ADME Research booth at 2013 AAPS National Meeting in San Antonio, Texas.

Zagreb – Then and now. Left: visit in 1999, during which pION Inc. presented its very first PAMPA
lecture at the Zagreb Medical School. Right: 2017, during IAPC-6 Meeting in Zagreb.

Research Chemist Dr. A. Avdeef (left) and Product Line Manager J. Comer (right) examine the experimental
test rig during the early stages of the development of the Orion Research 960 Autochemistry System. c. 1984.