Gull in Sunset. Rovinj, Croatia.
Sep 2009. (c) Copyright 2009 by
A. Avdeef.

DISSOLUTION SOLUBILITY PERMEABILITY
pKa

Publications with in-ADME Research Authors

(updated Jan. 2019)

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128. Avdeef A. Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments. ADMET & DMPK 6 (2018) 105-139.

127. Avdeef A. Cocrystal solubility product prediction using an in combo model and simulations to improve design of experiments. Pharm. Res. (2018), 35: 40. https://doi.org/10.1007/s11095-018-2343-3

126. Lozoya-Agullo I, Gonzalez-Alvarez I, Zur M, Fine-Shamir N, Cohen Y, Markovic M, Garrigues TM, Dahan A, Gonzalez-Alvarez M, Merino-Sanjuán M, Bermejo M, Avdeef A. Closed-loop Doluisio (colon, small intestine) and single-pass intestinal perfusion (colon, jejunum) in rat – biophysical model and predictions based on Caco-2. Pharm. Res. (2018) 35: 2. https://doi.org/10.1007/s11095-017-2331-z

125. Yusof SR, Abbott NJ, Avdeef A. Impact of capillary flow hydrodynamics on carrier-mediated transport of opioid derivatives at the blood-brain barrier, based on pH-dependent Michaelis-Menten and Crone-Renkin analyses. Eur. J. Pharm. Sci. 2017, 106, 274-286.

124. Takács-Novák K, Urac M, Horváth P, Völgyi G, Anderson BD, Avdeef A. Equilibrium solubility measurement of compounds with low dissolution rate by Higuchi's Facilitated Dissolution Method. A validation study. Eur. J. Pharm. Sci. 2017, 106, 133-141.

123. Avdeef A. Cocrystal solubility product analysis – Dual concentration-pH mass action model not dependent on explicit solubility equations. Eur. J. Pharm. Sci. 2017, 110, 2-18.

122. Pobudkowska A, Ràfols C, Subirats X, Bosch E, Avdeef A. Phenothiazines solution complexity – determination of pKa and solubility-pH profiles exhibiting sub-micellar aggregation at 25 and 37 `C. Eur. J. Pharm. Sci. 2016, 93, 163-176.

121. Avdeef A, Fuguet E, Llinàs A, Ràfols C, Bosch E, Völgyi G, Verbić T, Boldyreva E, Takács-Novák K. Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality. ADMET & DMPK 2016, 4, 117-178.

120. Avdeef A. Solubility temperature dependence predicted from 2D structure. ADMET & DMPK 2015, 3, 298-344.

119. Butcher G, Comer J, Avdeef A. pKa-critical Interpretations of solubility–pH profiles: PG-300995 and NSC-639829 case studies. ADMET & DMPK 2015, 3(2), 131-140.

118. Avdeef A. Suggested improvements for measurement of equilibrium solubility-pH of ionizable drugs. ADMET & DMPK 2015, 3(2), 84-109.

117. Avdeef A, Deli MA, Neuhaus W. In-vitro assays for assessing BBB permeability: artificial membrane and cell culture models. In: Di L, Kerns EH (eds.). Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects. Wiley-Interscience. Hoboken, NJ. 2015, pp. 188-237.

116. Wang C, Avdeef A, Zhang W, Tam KY. Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. Bio-Med. Mat. Eng. 2014, 24, 3849–3854.

115. Yusof SR, Avdeef A, Abbott NJ. In vitro porcine blood-brain barrier model for permeability studies: pCEL-X software pKaFLUX method for aqueous boundary layer correction and detailed data analysis.Eur. J. Pharm. Sci. 2014, 65,98-111.

114. Smith D, Artursson P, Avdeef A, Di L, Ecker GF, Faller B, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, van de Waterbeemd H, Sugano K, Testa B. Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition.Mol. Pharmaceutics 2014, 11, 1727−1738.

113. Avdeef A. Phosphate Precipitates and Water-Soluble Aggregates in Re-examined Solubility-pH Data of Twenty-five Basic Drugs. ADMET & DMPK 2014, 2(1), 43-55.

112. Avdeef A. Anomalous Solubility Behavior of Several Acidic Drugs. ADMET & DMPK 2014, 2(1), 33-42.

111. Völgyi G, Marosi A, Takács-Novák K, Avdeef A. Salt Solubility Products of Diprenorphine Hydrochloride, Codeine and Lidocaine Hydrochlorides and Phosphates – Novel Method of Data Analysis Not Dependent on Explicit Solubility Equations. ADMET & DMPK 2013, 1(4), 48-62.

110. Reis JM, Dezani AB, Pereira TM, Avdeef A, Serra CHR. Lamivudine permeability study: A comparison between PAMPA, ex vivo and in situ Single-Pass Intestinal Perfusion (SPIP) in rat jejunum. Eur. J. Pharm. Sci. 2013, 48, 781-789.

109. Völgyi G, Vizserálek G, Takács-Novák K, Avdeef A, Tam KY. Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties. Eur J Pharm Sci. 2012, 47, 21-27.

108. Di L, Artursson P, Avdeef A, Ecker GF, Faller B, Fischer H, Brian Houston J, Kansy M, Kerns EH, Krämer SD, Lennernäs H, Sugano K. Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. Drug Discov. Today. 2012, 17, 905-912.

107. Sinkó B, Garrigues TM, Balogh GT, Nagy ZK, Tsinman O, Avdeef A, Takács-Novák K. Skin-PAMPA: a new method for fast prediction of skin penetration. Eur J Pharm Sci. 2012, 45, 698-707.

106.  Sun N, Avdeef A. Biorelevant pKa (37oC) Predicted from the 2D Structure of the Molecule and its pKa at 25oC.  J. Pharm. Biomed. Anal. 2011, 56, 173-182.

105.  Avdeef A, Sun N.  A new in situ brain perfusion flow correction method for lipophilic drugs based on the pH-dependent Crone- Renkin equation.  Pharm. Res. 2011, 28, 517-530.

104.  Tsinman O, Tsinman K, Sun N, Avdeef A.  Physicochemical selectivity of the BBB microenvironment governing passive diffusion – matching with a porcine brain lipid extract artificial membrane permeability model.  Pharm. Res. 2011, 28, 337-363.

103.  Avdeef A.  How well can in vitro barrier microcapillary endothelial cell models predict in vivo blood-brain barrier permeability? Eur. J. Pharm. Sci. 2011, 43, 109-124.

102.  Fagerberg JH, Tsinman O, Tsinman K, Sun N, Avdeef A, Bergström CAS.  Dissolution rate and apparent solubility of poorly soluble compounds in biorelevant dissolution media. Mol. Pharmaceutics 2010, 7, 1419-1430.

101.  Avdeef A, Tam KY. How well can the Caco-2/MDCK models predict effective human jejunal permeability? J. Med. Chem. 2010, 53, 3566-3584.

100. Sugano K, Kansy M, Artursson P, Avdeef A, Bendels S, Di L, Ecker GF, Faller B,  Fischer H, Gerebtzoff G, Lennernäs H, Senner F. Coexistence of passive and active carrier-mediated uptake processes in drug transport: a more balanced view. Nature Rev. Drug Discov. 2010, 9, 597-614.

99.  Avdeef A. Leakiness and size exclusion of paracellular channels in cultured epithelial cell monolayers – interlaboratory comparison. Pharm. Res. 2010, 27, 480-489. 

98. Tam KY, Avdeef A, Tsinman O, Sun N.  The permeation of amphoteric drugs through artificial membranes – an in combo absorption model based on paracellular and transmembrane permeability.  J. Med. Chem. 2010, 53, 392-401.

97.  Sinkó B, Kökösi J, Avdeef A, Takács-Novák K.  A PAMPA study of the permeability-enhancing effect of new ceramide analogues. Chem Biodivers. 2009, 11, 1867-74.

96. Avdeef A, Tsinman K, Tsinman O, Sun N, Voloboy D. Miniaturization of powder dissolution measurement and estimation of particle size. Chem. Biodiv. 2009,11, 1796-1811.

95. Dagenais C, Avdeef A, Tsinman O, Dudley A, Beliveau R. P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model.  Eur. J. Pharm. Sci. 2009, 38, 121-137.

94. Tsinman K, Avdeef A, Tsinman O, Voloboy D. Powder dissolution method for estimating rotating disk intrinsic dissolution rates of low solubility drugs. Pharm. Res. 2009, 26, 2093-2100.

93. Avdeef A, Tsinman O. Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional Wood’s apparatus. Pharm. Res. 2008, 25, 2613-2627.

92. Escher BI, Berger C, Bramaz N, Kwon J-H, Richter M, Tsinman O,  Avdeef A. Membrane-water partitioning, membrane permeability and non-target modes of action in aquatic organisms of the parasiticides ivermectin, ablendazole and morantel. Envir. Tox. Chem. 2008, 27, 909-918.

91. Avdeef A, Kansy M, Bendels S, Tsinman K. Absorption-excipient-pH classification gradient maps: sparingly-soluble drugs and the pH partition hypothesis. Eur. J. Pharm. Sci. 2008, 33, 29-41.

90. Berger CM, Tsinman O, Voloboy D, Lipp D, Stones S, Avdeef A. Miniaturized intrinsic dissolution rate (Mini-IDR™) measurement of griseofulvin and carbamazepine. Dissolut .Tech. 2007, 14, 39-41.

89. Avdeef A, Bendels S, Di L, Faller B, Kansy M, Sugano K, Yamauchi Y. PAMPA - a useful tool in drug discovery.  J. Pharm. Sci. 2007, 96, 2893-2909.

88. Avdeef A. Solubility of sparingly-soluble drugs. Dressman J, Reppas C. (eds., special issue: The Importance of Drug Solubility).  Adv. Drug Deliv. Rev. 2007, 59, 568-590.

87. Avdeef A. Drug ionization and physicochemical profiling. In: Mannhold R. (ed.), Drug Properties: Measurement and Computation, Wiley-VCH, 2007, pp. 55-83.

86. Avdeef A, Voloboy D, Foreman A.  Dissolution and solubility.  In: Testa B, van de Waterbeemd H (eds.). Comprehensive Medicinal Chemistry II, Elsevier: Oxford, UK, 2007, pp. 399-423.

85. Avdeef A, Bendels S, Tsinman O, Kansy M. Solubility–excipient classification gradient maps. Pharm. Res. 2007, 24, 530-545.

84. Fischer H, Kansy M, Avdeef A, Senner F. Permeation of permanently charged molecules through artificial membranes – influence of physicochemical properties. Eur. J. Pharm. Sci. 2007, 31, 32-42.

83. Bendels S, Tsinman O, Wagner B, Lipp D, Parrilla I, Kansy M, Avdeef A. PAMPA-excipient classification gradient maps. Pharm.Res. 2006, 23, 2525-2535.

82. Avdeef A. HT solubility and permeability: MAD-PAMPA analysis.   In: Testa B, Krämer SD, Wunderli-Allenspach H, Folkers G (eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies. Wiley-VCH: Weinheim, 2006, pp. 221-241.

81. Avdeef A, Tsinman O. PAMPA –a drug absorption in vitro model. 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA. Eur. J. Pharm. Sci., 2006, 28, 43-50.

80. Avdeef A.  The rise of PAMPA.  Expert Opinion Drug Metab. Tox. 2005, 1, 325-342.

79. Kansy M, Avdeef A, Fischer H.  Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists.  Drug Discovery Today: Technologies 2005, 1, 349-355.

78. Avdeef A,  Artursson P,  Neuhoff S, Lazarova L, Gräsjö J, Tavelin S. Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pKaflux method. Eur. J. Pharm. Sci., 2005, 24, 333-349.

77. Ruell JA, Avdeef A. Absorption using the PAMPA approach. In: Yan Z, Caldwell GW (eds.), Optimization in Drug Discovery: In Vitro Methods. The Humana Press: Totowa, NJ, 2004, pp. 37-64.

76. Ruell JA, Tsinman O, Avdeef A.  Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules. Chem. Pharm. Bull., 2004, 52, 561-565

75. Avdeef A, Nielsen PE, Tsinman O.  PAMPA - a drug absorption in vitro model. 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates. Eur.J Pharm.Sci., 2004, 22, 365-374.

74. Caron G, Ermondi G, Damiano A, Novaroli L, Tsinman O, Ruell JA, Avdeef A.  Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine. Bioorg. Med. Chem. 2004, 23, 6107-6118.

73. Nielsen P, Avdeef A.  PAMPA - a drug absorption in vitro model. 8.  Apparent filter porosity and the unstirred water  layer. Eur. J. Pharm. Sci., 2004, 22, 33-41.

72. Bermejo, M. Avdeef, A. Ruiz, A. Nalda, R. Ruell, J.A. Tsinman, O. González, I. Fernández, C. Sánchez, G. Garrigues, T.M. Merino, V. PAMPA - a drug absorption in vitro model. 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur. J. Pharm. Sci. 2004, 21, 429-441.

71. Didziapetris R, Japertas P, Avdeef A, Petrauskas A.  Classification analysis of P-glycoprotein substrate specificity. J. Drug Target. 2003, 11, 391-406.

70. Avdeef A. Absorption and Drug Development. Wiley-Intercience: New York. 2003.  

69. Youdim KA, Avdeef A, Abbott NJ.  In vitro trans-monolayer permeability calculations: often forgotten assumptions. Drug Disc. Today, 2003, 8, 997-1003.

68. Ruell JA, Tsinman KL, Avdeef A. PAMPA - a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKaflux - optimized design (pOD-PAMPA).  Eur. J. Pharm. Sci. 2003, 20, 393-402.

67. Liu H, Sabus C, Carter GT. Du C, Avdeef A, Tischler M.  Solubilizer selection in the parallel artificial membrane permeability assay (PAMPA) for in vitro permeability measurement of low solubility compounds. Pharm. Res. 2003, 20, 1820-1826.

66. McFarland JW, Du CM, Avdeef A.  Factors influencing the water solubility of crystalline drugs.  In: van de Waterbeemd H, Lennernäs H, Artursson P (eds.). Drug Bioavailability.  Estimation of Solubility, Permeability, Absorption and Bioavailability. Wiley - VCH: Weinheim, 2003, pp. 232-242.

65. Avdeef A. High-throughput measurement of membrane permeability. In: van de Waterbeemd H, Lennernäs H, Artursson P. (eds.). Drug Bioavailability/Estimation of Solubility, Permeability, Absorption and Bioavailability.  Wiley- VCH: Weinheim, 2003, pp. 46-71.

64. Ruell J, Avdeef A.  A measured solution. Modern Drug Disc. 2003, June issue, 47-49.

63. Zmuidinavicius D, Didziapetris R, Japertas P, Avdeef A, Petrauskas A.  Classification structure-activity relations (C-SAR) in prediction of human intestinal absorption. J. Pharm. Sci. 2003, 92, 621-633.

62. Avdeef A, Testa B. Physicochemical profiling in drug research: a brief state-of-the-art of experimental techniques. Cell. Molec. Life Sci. 2003, 59, 1681-1689.

61. Bergström CAS, Strafford M, Lazarova L, Avdeef A, Luthman K, Artursson P.  Absorption classification of oral drugs based on molecular surface properties. J. Med. Chem. 2003, 46, 558-570.

60. Toher CJ , Nielsen PE, Foreman AS, Avdeef A.  In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation. Dissol. Technol. 2003, 10, 20-25.

59. McFarland JW, Avdeef A, Berger CM, Raevsky OA.  Estimating the water solubilities of crystalline compounds from  their chemical structure alone.  J. Chem. Inf. Comput. Sci. 2001, 41, 1355-1359.

58. Avdeef A. Physicochemical profiling (permeability, solubility, charge state). Curr.Topics Med.Chem.2001, 1, 277- 351.

57. Avdeef A, Strafford M,  Block E, Balogh MP, Chambliss W, Khan I. Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper Methysticum Forst. Eur. J. Pharm. Sci. 2001, 14, 271-280.

56. Avdeef A.  High-throughput measurements of solubility profiles. In: Testa B, van de Waterbeemd H, Folkers G, Guy R (eds.), Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta: Zürich and Wiley-VCH: Weinheim, 2001, pp. 305-326.

55. Avdeef A, Berger CM. pH-metric solubility. 3.  Dissolution titration template method for solubility determination.  Eur. J. Pharm. Sci. 2001, 14, 271-280.

54. Avdeef A, Berger CM, Brownell C.  pH-metric solubility. 2.  Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods. Pharm. Res. 2000, 17, 85-89.

53. Caron G, Steyaert G, Pagliara A, Reymond F, Crivori P, Gaillard P, Carrupt P-A, Avdeef A, Comer J, Box KJ, Girault HH, Testa B. Structure-lipophilicity relationships of neutral and protonated β-blockers. 1. Intra and intermolecular effects in isotropic solvent systems. Helv. Chim. Acta, 1999, 82, 1211-1222.

52. Avdeef A, Box KJ, Comer JEA, Gilges M, Hadley M, Hibbert C, Patterson W, Tam KY.  pH-metric log P. 11. pKa  determination of water-insoluble drugs in organic solvent-water mixtures. J.Pharm.Biomed.Anal., 1999, 20, 631-641.

51. Avdeef A.  pH-metric solubility. 1. Solubility-pH profiles from Bjerrum plots. Gibbs buffer and pKa in the solid state.  Pharm. Pharmacol. Commun., 1998, 4, 165-178.

50. Avdeef A, Box KJ, Comer JEA, Hibbert C, Tam KY.  pH-metric log P. 10. Determination of vesicle membrane – water partition coefficients of ionizable drugs. Pharm. Res. 1997, 15, 208-214.

49. Takács-Novák K, Box KJ, Avdeef A.  Potentiometric pKa determination of water-insoluble compounds. Validation study in methanol/water mixtures.  Int. J. Pharm. 1997, 151, 235-248.

48. Avdeef A,  Box KJ. Sirius Technical Application Notes 1996, 2. (200-page book, ISBN 1-901125-05-X).

47.  Takács-Novák K, Avdeef A.  Interlaboratory study of logP determination by shake-flask and potentiometric methods.  J. Pharm. Biomed. Anal. 1996, 14, 1405-1413.

46. Avdeef A.  Assessment of distribution - pH profiles.  In Pliska V, Testa B, van de Waterbeemd H (eds.). Methods and            Principles in Medicinal Chemistry, Vol.4, VCH Publishers: Weinheim, Germany, 1996, pp.109-139. 

45. Avdeef A, Barrett DA, Shaw PN, Knaggs RD, Davis SS. Octanol-, chloroform-, and PGDP-water partitioning of morphine-6-glucuronide and other related opiates.  J. Med. Chem. 1996, 39, 4377-4381.

44. Avdeef A, Takács-Novák K, Box KJ. pH-metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the octanol-water partitioning with prostaglandins E1 and E2. J. Pharm. Sci. 1995, 84, 523-529. 

43. Avdeef A, Sirius Technical Application Notes 1995, 1. (220-page book, ISBN 1-901125-00-9).

42. Comer JEA, Avdeef A, Box KJ. Limits for successful measurement of pKa and log P by pH-metric titration. Amer. Lab. 1995, 4, 36c-36i. 

41. Comer JEA, Avdeef A, Box KJ, Internatl. Lab. News 1994, 12, 12. 

40. Takács-Novák K, Avdeef A, Podányi B, Szász G. Determination of protonation macro- and microconstants and octanol/water partition coefficient of antiinflammatory niflumic acid. J. Pharm. Biomed. Anal. 1994, 12, 1369-1377.

39. Slater B, McCormack A, Avdeef A, Comer JEA.  pH-metric log P. 4. Comparison of partition coefficients determined by HPLC and potentiometric methods to literature values. J. Pharm. Sci. 1994, 83, 1280-1283.

38. Avdeef A. pH-Metric pKa and logP Determination, Applications and Theory Guide, Sirius Analytical Instruments Ltd., Forest Row, E.Sussex, UK, 330-page book, 1993.  

37. Avdeef A, Comer JEA. Measurement of pKa and log P of water-insoluble substances by potentiometric titration. In: Wermuth CG (ed.), QSAR and Molecular Modelling, Escom: Leiden, 1993, pp. 386-387. 

36. Avdeef A, Comer JEA, Thomson SJ. pH-metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances. Anal. Chem.1993, 65, 42-49. 

35. Avdeef A. pH-metric log P. 2. Refinement of partition coefficients and ionization constants of multiprotic substances.  J. Pharm. Sci. 1993, 82, 183-190. 

34. Avdeef A, Comer JEA.  Measurement of pKa and log P of water-insoluble substances by potentiometric titration. In: Wermuth, C.G. (Ed.). QSAR and Molecular Modelling, Escom: Leiden, 1993, pp. 386-387.

33. Avdeef A. pH-metric log P. 1. Difference plots for determining ion-pair octanol-water partition coefficients of multiprotic substances. Quant. Struct.- Act. Relat. 1992, 11, 510-517. 

31. Avdeef A, Hartenstein F, Chemotti AR Jr., Brown JA. Cadmium binding by biological ligands. 5. Solution studies of cadmium and zinc binding by sulfhydryl ligands N,N'-dimethyl-N,N'-bis(2-mercaptoethyl)ethylenediamine and (2-mercaptoethyl)amine. Inorg.Chem.1992, 31, 3701-3705. 

32. Avdeef A.  Fast simultaneous determination of log P and pKa by potentiometry: para-alkoxyphenol series (methoxy to pentoxy).  In: Silipo C, Vittoria A (eds.). QSAR: Rational Approaches to the Design of Bioactive Compounds,  Elsevier: Amsterdam, 1991, pp.119-122. 

30. Avdeef A, Chemotti AR Jr.Cadmium binding by biological ligands. 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid. J. Chem. Soc. Dalton Trans. 1991, 1189-1194. 

29. Avdeef A, Comer J. Orion 960: un analyseur potentiométrique multifonction. Analusis 1988, 16, 63-68. 

28. Avdeef A, Comer J. A versatile potentiometric analyzer. Part 2. Multiple known addition and Gran titration techniques. Amer. Lab. 1987, 19(4), 116-124. 

27. Avdeef A, Comer J. A versatile potentiometric analyzer. Part 1. Hardware, the user interface, and titration techniques. Amer. Lab. 1987, 19(2), 116-125.  

26. Comer J, Avdeef A. Enhancing the performance of ion-selective electrodes, by multiple, incremental, titration and Gran techniques. Intl. Lab. 1987, 12, 11-14.  

25. Avdeef A. STBLTY: methods for construction and refinement of equilibrium models. In: Leggett DJ (ed.), Computational Methods for the Determination of Formation Constants, Plenum: New York, 1985, pp. 355-473. 

24. Avdeef A, Zelazowski AJ, Garvey JS. Cadmium binding by biological ligands. 3. five- and seven-cadmium binding in metallothionein: a detailed thermodynamic study. Inorg. Chem.1985, 24, 1928-1933. 

23. Avdeef A, Brown J. Cadmium binding by biological ligands. 2. formation of protonated and polynuclear complexes between cadmium and 2-mercaptoethylamine. Inorg. Chim. Acta 1984, 17, 67-73.  

22. Avdeef A.Weighting scheme for regression analysis using pH data from acid-base titrations. Anal. Chim. Acta 1983, 148, 237-244. 

21. Avdeef A, Zabronsky J, Stuting HH. Calibration of copper ion selective electrode response to pCu 19. Anal. Chem. 1983, 55, 298-304. 

20. Avdeef A, Kearney DL. Cadmium binding by biological ligands. 1. Formation of protonated polynuclear complexes between cadmium and D-penicillamine in aqueous solution. J. Amer. Chem. Soc. 1982, 104, 7212-7218. 

19. Avdeef A. Soviet Scientific Reviews, Sec. B. Chemical Reviews, Vol. 3. J. Amer. Chem. Soc. 1982, 104, 4736.

18. Avdeef A, Kearney DL, Brown JA, Chemotti AR Jr.  Bjerrum plots for the determination of systematic concentration errors in titration data. Anal. Chem.1982, 54, 2322-2326. 

17. Avdeef A. Cadmium chemicals. J. Amer. Chem. Soc. 1980, 102, 7829. 

16. Avdeef A. Composition of ternary (metal-ligand-hydrogen) complexes experimentally determined from titrations using only a pH electrode. Inorg. Chem. 1980, 19, 3081-3086. 

15. Harris WR, Carrano CJ, Cooper SR, Sofen SR, Avdeef A, McArdle JV, Raymond KN. Coordination chemistry of microbial iron transport compounds. 19. Stability constants and electrochemical behavior of ferric enterobactin and model complexes. J. Amer. Chem. Soc. 1979, 101, 6097-6104. 

14. Avdeef A, Raymond KN. Free metal and free ligand concentrations determined from titrations using only a pH electrode. Partial derivatives in equilibrium studies. Inorg. Chem.1979, 18, 1605-1611. 

13. Avdeef A, Bucher JJ. Accurate measurements of the concentration of hydrogen ions with a glass electrode: calibrations using the Prideaux and other universal buffer solutions and a computer-controlled automatic titrator.  Anal. Chem. 1978, 50, 2137-2142. 

12. Avdeef A, Sofen SR, Bregante TL, Raymond KN. Coordination isomers of microbial iron transport compounds. 9. Stability constants for catechol models of enterobactin. J. Amer. Chem. Soc. 1978, 100, 5362-5370. 

11. Avdeef A, Fackler JPJr. Studies of the cubane cluster of copper(I).  A modified self-consistent charge and configuration molecular orbital study of the cluster containing the Cu8S124- core. Inorg.Chem.1978, 17, 2182-2187. 

10.  Avdeef A, Schaefer WP.Reversible oxygen carriers.  The synthesis and low temperature (-171oC) structure of an unstable monomeric dioxygen adduct of N,N'-(1,1,2,2-tetramethyl)ethylenebis(3-fluorosalicylideniminato)(1-methylimidazole)cobalt(II), Co(3-F-Saltmen)(1-Me-Imid)(O2).2(CH3)2CO.J. Amer. Chem. Soc. 1976, 98, 5153-5159.  

9.    Avdeef A, Schaefer WP. Reversible oxygen carriers.  Synthesis and structure of µ-Dioxygen-bis[N,N'-ethylenebis-(salicylideniminato)piperidenecobalt] acetonate piperidinate, (C5H11NCoSalen)2(O2).0.67(CH3)2CO.0.33C5H11N7.Inorg. Chem. 1976, 15, 1432-1440.  

8.    Avdeef A,  Fackler JP Jr.  Structural trends of tris(acetylacetonate)-, tris(tropolonate)- and other tris(bidentate ligand)-metal complexes.  Additional comments on the trigonal twist and ligand-ligand repulsions in 'octahedral' D3 bidentate ligand-metal complexes. Inorg. Chem. 1975, 14, 2002-2006.  

7.    Avdeef A, Fackler JPJr. Bis(triphenylphosphine)ethyltrithiocarbonato-copper(I). J. Coord. Chem. 1975, 4, 211-215.  

6.    Fackler JP Jr,  Avdeef A.  Crystal and molecular structure of tris(2,4-pentanedionato)manganese(III), Mn(O2C5H7)3, a distorted complex as predicted by Jahn-Teller arguments. Inorg. Chem. 1974, 13, 1864-1875.  

5.    Avdeef A, Costamagna JA, Fackler JP Jr. Crystal and molecular structure of tris(tropolonato)manganese(III), Mn(O2C7H5)3, a high-spin complex having structural features consistent with Jahn-Teller behavior for two distinct MnO6 centers. Inorg. Chem. 1974, 13, 1854-1863.  

4.    Fackler JP Jr, Avdeef A, Fischer RG Jr. Sulfur chelates. 16. Chemical properties of oxidized nickel(II) dithiocarbamates.  The X-ray crystal structure of tris(N,N-di-n-butyldithiocarbamato)nickel(IV) bromide, NiC27H54S6Br.  J. Amer. Chem. Soc. 1973, 95, 774-782.  

3.    Avdeef A, Fackler JP Jr. Computer generation of cubic molecular symmetry orbitals. Inorg. Chem. 1973, 12, 713-716.  

2.    Avdeef A, Raymond KN, Hodgson KO, Zalkin A. Two isostructural actinide complexes.  The crystal and molecular structures of bis(cyclooctatetraenyl)uranium(IV), U(C8H8)2, and bis(cyclooctatetraenyl)thorium(IV), Th(C8H8)2. Inorg. Chem. 1972, 11, 1083-1088.  

1.    Avdeef A, Fackler JP Jr, Fischer RG Jr. Structural characterization of tris (N,N-di-n-butyldithio-carbamato)nickel(IV) bromide.  A NiS6 complex with unusual chemical properties. J. Amer. Chem. Soc. 1970, 92, 6972-6974.  

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